Powerful New Supplement Targets Brain Plaques And Tangles

This is a “sponsored post.” Percepta compensated FOF with an advertising sponsorship to write it. Regardless, we only recommend products or services that we believe will be helpful for our readers. All insights and expressed opinions are our own. —Geri Brin

I can fanatically floss and dutifully diet to help control the soft and sticky stuff on my teeth and the fatty buildup in the right carotid artery in my neck. But there’s not much I can do if impenetrable plaques accumulate between the nerve cells in my brain, and start to rob my memory and destroy my mind. Naturally, it got my attention when I heard about an exciting, new and natural plant-based supplement that’s more powerful than any other for targeting out-of-control brain “plaques” and “tangles.”  They’re the real reasons we lose memory as we age.  I’m not afraid of much. I’m petrified of losing my mind.

Anxious to learn more, I arranged for an interview with Dr. Alan Snow, one of the two neuroscientists behind the new supplement who has spent decades studying brain health and the aging brain. “We’re all walking around with a bunch of  plaques and tangles in our brains, starting in our early to mid-20s,” Dr. Snow said. “We now know they’re there, but no one knows with certainty why they accumulate and cause memory loss in people as they age.”

Plaques and tangles, both forms of protein, can become partners in crime.  Plaques–hard, insoluble clumps of amyloid protein fragments–settle between nerve cells in the brain, and look like “giant meatballs,” Dr. Snow told me. In a healthy brain, protective cells from our immune system recognize the plaque as an enemy and move in to destroy their protein fragments. In some people, the protective cells misfire,  killing healthy brain cells instead, and actually trigger the production of even more harmful plaques as well as neuroinflammation. The plaques can literally stand in the way of our nerve cells talking to each other. This prevents us from forming coherent thoughts or sharp memories.

Brain tangles of tau protein

Tangles–tau protein–are twisted fibers that live inside the cells and look like “dried-up spaghetti,”  Dr. Snow said.  In healthy brain cells, the protein normally supports essential structures that carry nutrients and other important substances from one part of the nerve cell to another. In brain aging, the tau protein may be abnormal, the structures collapse and the cells die.

Newer research also has established the link between neuroinflammation and memory loss, “although we don’t know the cause of the inflammation,” Dr. Snow added. “We think some people might have problems with brain inflammation later in life. Others can live to be 100 years old and have brains filled with plaques and tangles, but their memories stay basically intact.  They don’t have inflammation in the brain,” explained Dr Snow, who calls the combination of plaques, tangles and inflammation “the memory loss trilogy.”


Percepta, Dr. Snow’s new supplement, is made with PTI-00703® cat’s claw, a natural plant extract from a wild, woody vine in the Amazon rainforest. The plant’s thorns, by the way, are shaped like a cat’s claw! “I’ve been working in the drug development field for brain aging for over 30 years and have never seen a more potent inhibitor of both plaques and tangles than the cat’s claw that we discovered,” Dr. Snow said confidently. 

Dr. Snow and a team of research scientists  at the University of Washington began studying the interaction between  different dietary supplements and amyloid plaques about two decades ago. Testing dozens of nutraceuticals purchased from a Seattle vitamin shop, they were exhilarated when one of them took only a few minutes to disintegrate the plaque they had replicated in a test tube.  It was a mixture of cat’s claw and glucosamine, so Dr. Snow next tested each ingredient separately. “The cat’s claw was able to stop the plaques from forming in a particular way, but once they did form, it dissolved them in a few minutes. “As soon as we added the cat’s claw to the test tube, the plaques broke apart and were gone!” Dr. Snow said.  Dr. Snow later discovered cat’s claw had the same effect on tangles in the brain.

          Cat’s Claw

Dr. Snow tested the PTI-00703® cat’s claw on mice that had been genetically engineered to grow plaques in their brains as they aged. The major newly discovered polyphenol in cat’s claw (known as proanthocyanidin B2) by the Snow research team decreased plaques in older mice by 52 to 58% and in younger mice by 74 to 83% over a three-month period. The reduction of brain plaques also led to a 58% improvement in short-term memory, almost back to normal. This work was finally published in a 109-page paper in Nature- Scientific Reports on February 6, 2019, by Snow et al. It represented over 10 years of scientific studies on the effects of PTI-00703® cat’s claw on brain plaques, tangles and inflammation, and included over eight different institutions involved in different aspects of the studies.


Cat’s claw isn’t a new supplement. The Inca civilization used it for medicinal purposes. Today, at least  dozens of brands market cat’s claw capsules, liquids and powders for everything from fighting viral infections to stimulating the immune system. But the cat’s claw in Percepta® is superior to any other, Dr. Snow asserted. “We tested brands from 18 different companies all over the world, and located a high elevation in the Amazon rainforest that grows the most potent cat’s claw we have ever seen for specifically targeting brain plaques, tangles and inflammation,” he explained. “And, the proprietary process we use to extract our cat’s claw from the plant’s bark and concentrate it into a powder seems to optimize its plaque and tangle dissolving activity.”  A second ingredient in Percepta is MemorTeaTM, a specific oolong tea extract from the mountains of China. “Partially oxidized and partially fermented, our research demonstrated that oolong tea acts more potently on plaques than black and green tea,” Dr. Snow said. 

Oolong tea acts potently on brain plaques

Percepta has 50 global patents covering cat’s claw for brain health, including cognition, short term memory, focus, concentration and executive function. “We had to stop a couple of supplement companies from claiming their cat’s claw was good for brain health because they were infringing on our patents,” Dr. Snow said.

“Exercising, sleeping well, and reducing stress have everything to do with helping to clear out the plaque load that accumulates in your brain so it will function better. One-third of memory loss cases can be prevented by lifestyle changes,” Dr. Snow stressed.  And make sure to add Percepta to your smart schedule. Each two-capsule dose works for about 24 hours, which is how long it takes for plaques to turn over in our brain. “Most people see an increase in memory, focus and/or concentration within a few weeks,” Dr. Snow said.  “One woman with brain tangles from multiple concussions had memories she hasn’t had in 13 years after she started taking Percepta.”

  • Linda Pollack Martin

    This kind of advertising gets me furious. Please do not advertise for a drug to help with dementia. Alzheimer’s (which usually consist of tau and amyloid plaque) has been cured in mice many times. It has not translated to humans at this point. You are promoting a ‘drug’ (whether it’s natural or pharmaceutical) that has not been proven in large trials, nor has it been approved by the FDA. You need to be careful about this. I am a volunteer Advocate (on the state and federal levels) for the Northern California Alzheimer’s Association. Please go to alz.org or contact your local Alzheimer’s Association for more information on trials and available research. This number is manned 24/7: 800.272.3900

    • GeriFOF

      Hello Linda,

      May I recommend 1.) that you read the backgrounds of the scientists who created this supplement. Besides Dr. Alan Snow, who I interviewed, here is a link to Dr. Tanzi’s background https://www.madrc.org/members/10924 2.) read the article before commenting on it, because then you’d know that the article DOES NOT say the supplement “helps with dementia.” (Frankly, I don’t even know what that means). Thus nootropic IS NOT a drug, even if you choose to call it that.

      Dr. Snow and Dr. Tanzi are keenly aware of what can and cannot be said, so while I appreciate your advise “to be careful about this,” I can assure you that they have that well covered.

      It is admirable that you volunteer for the Northern California Alzheimer’s Association. I doubt, however, that you are more knowledgeable than two esteemed scientists and their teams who have spent decades on aging and dementia.

      Geri Brin