The #1 Selling Anti-Aging Body Treatment For Dry, Crepey Skin Just Got Even Better*

Crepe Erase® compensated FabOverFifty with an advertising sponsorship to write this post. Regardless, we only recommend products or services that we believe will help you. All insights and opinions are our own. —Geri Brin

I try to keep a reserve of the beauty products I love so I’m never caught empty handed. When I was about to reorder one of my favorite products, which makes the skin on my body the smoothest, firmest and most hydrated it’s felt in years, I noticed they’ve come out with an improved version. I love when a good thing gets even better, so I ordered right away.

Now, after using new Crepe Erase® Advanced for about six months, I’m more in love than ever!

Dry, delicate skin is common later in life, since our glands naturally produce less oil. And dry skin can crack, especially on our elbows and feet. What’s more, our skin loses its wonderful foundation of collagen and elastin as we age, making it loose and saggy on areas like our neck and chest, inner arms, even on our knees and hands. Looking almost like crepe paper, it’s called “crepey skin.” 

I first discovered Crepe Erase when I was invited to try it as the editor of a popular website. It jumped out at me because I remembered seeing the actress, Jane Seymour, talk about it on TV. She looks sensational, at 68, and has been using Crepe Erase for years, a fine endorsement right there! It’s also a big big seller on QVC, where they call it anti-aging for your body.”  That definitely got my attention.

Crepe Erase isn’t a glorified body lotion. Trust me, it feels like I’ve tried them ALL. The secret ingredient that powers Crepe Erase Advanced is TruFirm Complex, a powerful botanical blend specially formulated for dry, crepey, aging skin. Its three naturally derived extracts–apple, dill and sage–help reinforce our skin’s netting, so the skin can appear tighter and firmer, and look like it did when we were younger. Crepe Erase Advanced also contains nine Super Hydrators, including coconut oil, shea butter, cocoa butter, olive oil, beeswax, cassava and Vitamin E to deliver 48 hours of intense hydration. And, they absorb even faster and more effectively than the original formula to visibly smooth, firm and renew the skin.

A breakthrough in skin care science, TruFirm Complex is available exclusively in Crepe Erase! 

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Crepe Erase® is the #1 Selling Anti-Aging Body Treatment System for Dry, Crepey Skin*

(*Based on Crepe Erase® sales data & IRI & NPD sales data for 2017.)

The five-piece Deluxe Kit, Jane’s favorite, also treats your skin above the chin! 

Before stepping into the shower, I massage the luxurious and rejuvenating Refining Facial Scrub with TruFirm over my whole face, down to my neck.  It gently removes rough, dead skin cells to give me softer, smoother, firmer and brighter skin. Paraben free, too! 

In the shower, I grab my bottle of silky Body Smoothing Pre-Treatment with TruFirm and gentle exfoliators to lift away dead, rough surface cells and make my skin look smoother and more radiant. The lovely, fresh scent is a bonus! (By the way, don’t take long, hot showers because they’ll dry your skin even more!)  

After the shower, I massage the Advanced Body Repair Treatment with TruFirm into the crepey skin around my neck, chest, arms and legs. Just like its name says, this lightly whipped formula restores firmer, healthier-looking skin all over my body. Absorbs quickly and isn’t one bit greasy.

Even after a late night, I can count on my Flaw-Fix Eye Cream to instantly reduce the appearance of puffiness, dark circles, fine lines and wrinkles. It absorbs quickly and can be used at night and in the morning. Great as a hydrating mask, too. 

I never leave home without applying Restorative Facial Treatment, a  deluxe, ultra-hydrating formula with TruFirm and a blend of moisturizing oils. Along with its sister products, its plumps, smoothes and firms, and diminishes the look of fine lines and wrinkles. 

As I mentioned earlier, the skin on my body hasn’t felt this smooth and hydrated in many years. I’ve learned that the more consistently you use skincare products, the better the results.

Crepe Erase is so confident that you’ll love its products, it invites you to use them for 60 days, and, if you’re not satisfied, you can return the tubes–EVEN EMPTY–for a full refund, less s&h! This offer even gives me more confidence that these are quality beauty products. Plus, the line is incredibly reasonable in the first place!

There’s more. Order the Deluxe Kit and receive our 4-in-1 Eye Renewal Capsules as a free thank you gift. Packed with intense, concentrated moisturizers for an eye-opening experience. A $38 value.

and save on Crepe Erase Advanced + get FREE SHIPPING today!

We Can Finally Afford Personal Training When We Need It Most!

Keeping sane is going to take all our wits during these trying times. Keeping fit may be nearly impossible, what with gyms closed and our limited ability to take vigorous walks. Then there’s our proximity to the kitchen during our self-imposed (and crucial) quarantine. We can be super disciplined and start a daily exercise program, but that’s hard enough when life is relatively normal.

What if I said you could have a certified personal trainer – right at home – who would create a customized exercise program for you. Guide and motivate you. And, you could work out on your own time, for a fraction of the cost of a membership at even a moderately priced gym.

sneaking a chocolate covered graham

That’s just what I’m doing, thanks to Ladder, a brilliant new app created by fitness and tech experts.  And so can you. Ladder gives us real-time virtual access to personal trainers at a super affordable price. And, it gives trainers the chance to grow their businesses when they’ve lost access to the gyms where they work. “We wanted to offer a convenient solution to reversing unhealthy habits,” said Randi Stock,  a Ladder spokeswoman. And, it’s certainly easy to ignore healthy habits during this trying time in all our lives.

MEET YOUR PERSONAL TRAINER TODAY 

It’s simple and quick to be matched with your perfect coach, receive your personalized program and get started.   

STEP 1

Answer eight questions about your personality and fitness, such as Would you rather do something new, something familiar or both? and How would you describe your general health? 

STEP 2

You’ll get a message from your new coach right on the Ladder app, where you get to know each other. My coach, Bobby, asked me about my experience with exercising, my goals, how many days during the week I’d like to dedicate to working out, my diet, injuries, physical limitations and access to exercise equipment.   

                       the body weight squat

Learning that I try to stay away from carbs because I can’t help binging on them, Bobby responded, “Most of the internet tends to make carbs out as ‘evil,’ when they actually can be really good sources of disposable energy!  To lose weight, it all depends on putting out more calories than we take in. Those calories can be carbs, fats, or protein, but at the end of the day it’s calories that matter.” Bobby then asked if I’d be open to recording my meals, which would help me be more conscious about my diet. I said I would. 

By the way, even if you don’t have a single piece of apparatus, your coach will design your custom at-home workout based on your comfort level and whether you want help building strength, increasing mobility or just staying active and healthy. He or she also will make sure the program works with any past injuries or existing health conditions.

 

STEP 3

Your coach will send your workout routine to your iPhone or iPad through the Ladder app, which is formatted beautifully.  Each exercise is slowly and clearly demonstrated on a short (20 seconds max) how-to video, which is accompanied by a concise written description. Your custom routine is created from Ladder’s extensive library of exclusive videos. When you’ve completed each workout, you send your coach a notification so she can see what you’re accomplishing. 

Based on my two weeks of experience, it works best to watch a video, try the exercise, then read the description.  After repeatedly doing the exercises you won’t need the videos or descriptions, but it’s still smart to watch precisely how they’re done once in a while. They’re great reference tools to look at as you go through your workout.

If you’re still not sure how to do an exercise, you can text your coach right on the app, which I did a number of times when I  was starting out. I also sent Bobby short videos of me performing a couple of exercises so he could critique my form.

Bobby is one of about 150 expert trainers across the country who are perfect fits for the Ladder platform. But it doesn’t matter where they’re located since you’ll be working out virtually. What matters is that you’ll be getting a progressive program that really works for you.  That’s worlds better than self-prescribing exercises you think you might need right off of the internet but won’t necessarily help you achieve your goals. 

What’s more, a real person will push and cheer you on so you get and stay motivated. Your Apple watch or a YouTube video can’t offer the crucial human element. And, as you give your trainer feedback, your program will become more and more customized for your level of expertise. “The more feedback you provide, the better your experience will be,” Randi stressed

            one of the exclusive videos from the Ladder library

Feeling pretty sore after I started exercising, for example, I asked Bobby if I should work through it. He suggested a  mobility routine which wouldn’t be overly strenuous but would keep me active and alleviate some of the soreness. It worked! 

“You develop a relationship with your coach, who is invested in your success right along with you. Ladder creates a system of accountability between the two of you,” Randi stressed.  

Bobby and I have established a pretty good daily communication system since we started working together a couple of weeks ago.  We often message in real time. Ladder encourages all trainers to get back to clients within a few hours. 

“Fitness is critical for longevity, especially as you age and your body’s performance starts to  decrease before you even turn 50,” Bobby said. “It’s especially important during this stressful time to keep your body moving and give it exactly what it needs! Ladder lets me customize  workout sessions for every individual and coach them on habits, nutrition, and more through the app! I love tailoring my clients’ routined to their lifestyles and to discover how they can fine-tune their health from all angles!”

I know the exercises are working because my muscles – which were extraordinarily tight  – are now limber. And, the routines are becoming easier. Once I master the round of current workouts, Bobby will send me a new one!  Recording my meals has also helped me stay on the right track.  (Psst: I’m afraid to cheat because I don’t want to tell Bobby, and I’m a bad liar, so I guess being accountable and building up good daily habits are good things.) 

THERE ISN’T A BETTER TIME TO START WORKING OUT WITH YOUR OWN DIGITAL PERSONAL TRAINER AT HOME. 

AND GET TWO WEEKS FREE, EXCLUSIVELY FOR THE FABOVERFIFTY COMMUNITY.

(After that, the cost is phenomenal, as in super reasonable).

Honoring His Treatment Experience After a Leukemia Diagnosis

This post was developed in collaboration with Novartis

During a Sunday phone call 15 years ago, Mitch learned he had leukemia from a doctor who talked so fast, Mitch couldn’t make out his name. His own doctor had told him the day before that his white blood cell count was off on his recent blood tests, and she wanted him to see a specialist right away. She never mentioned leukemia. Being a “broad brushstroke kind of guy,” Mitch didn’t ask questions. He’d learn what was up from the specialist, he thought.

Engaged in his treatment: Actual patient Mitch discusses his journey with CML

When the fast‐talking doctor called, he asked Mitch a litany of questions about his health. “‘Did you ever have this? Did you ever feel that?’” Mitch remembered him asking. When Mitch responded no to all the questions, the doctor said, “That’s great, because with leukemia we tend to think of these things.” He then told Mitch to have a good day and hung up!

“My wife was out with a girlfriend and I was alone,” said Mitch, a small business owner in Biddeford, ME, who was 45 years old at the time. “I was in a mild state of shock. When you hear the word ‘leukemia’, it doesn’t exactly conjure up the idea that this will be fine.” He tried not to dwell on it for the rest of the day. “I’ll know what I’ll be facing when I see the specialist tomorrow,” Mitch remembered thinking. He never learned the identity of fast talker. He just knows that was probably the worst phone call of his life.

“It’s the classic signature of Ph+ CML, and we’ve got to get your white blood cell count down,” the specialist matter-of-factly told Mitch. “You’d be in the hospital if the count was any higher. After that, we’re going to introduce you to a drug that’s been very successful in treating this type of leukemia,” the doctor explained to Mitch.

Ph+ CML are the initials for Philadelphia chromosome–positive chronic myeloid leukemia – a type of blood and bone marrow cancer which is associated with a mutation in the genes called the Philadelphia (Ph) chromosome. This triggers the bone marrow to grow abnormal white blood cells uncontrollably. This form of leukemia is most often diagnosed in people over 60, but can occur in younger adults, as it did with Mitch.

The specialist made it clear that Mitch had a serious illness known as Ph+ CML in chronic phase and needed treatment. Other than feeling “a little tired and out of sorts,” Mitch said he had no other symptoms. “I was working 60 or 70 hours a week. Being tired and feeling out of sorts at times is part and parcel of the whole thing, so I didn’t think anything of it,” Mitch noted.

THE TREATMENT JOURNEY: BUMPY, THEN SMOOTH SAILING

Over the next five years, Mitch’s leukemia was treated with two drugs, and while they kept his white blood cell count in check, he faced unfortunate side effects. Fortunately, another drug – Tasigna® (nilotinib) capsules – had received FDA approval by this time, and patients like Mitch, who endured side effects with other drugs, were having some success with this one. Tasigna can cause side effects, however, such as headache, nausea and potentially other serious outcomes.

Mitch has been taking Tasigna twice a day for the last 10 years, and his white blood cell count is under control. While the experience with Tasigna is different for every patient, Mitch has not reported experiencing side effects “worth mentioning.” After his doctors cautioned him about a potential side effect called QTc prolongation, a serious and possibly life‐threatening heart problem that causes an irregular heartbeat, Mitch is careful to note if he becomes lightheaded, faint or senses an irregular heartbeat.

Mitch is proud of his role in his treatment process for Ph+ CML: Going for blood work every single week, at first, to determine his white blood count and giving bone marrow samples once a month. “It’s like ice core drilling in the Arctic,” Mitch jested. “They use a small core drill to take marrow from my hip.” He takes Tasigna twice a day, 12 hours apart. What’s more, he also can’t eat for two hours before and one hour after his dose.

“It’s my responsibility to honor the process,” Mitch advised. “You really need to be engaged in your treatment. How can I expect the most out of my doctor if I’m not giving it my best? I’m part of a club and I have an obligation to follow the rules. It’s not just about me; it’s about my family. And, it’s about the thousands of people who worked incredibly hard to bring this drug to market, which makes an impact on the lives of thousands every year.”

Mitch hopes his own experience will help others who have been diagnosed with Ph+ CML, which is why he’s excited to be part of an important Tasigna campaign called Your Blood Demands to Be Heard. “If you own your treatment journey every step of the way, as I’ve owned mine, you can have a better chance for success,” he stressed.

Mitch has inspirational overarching advice for anyone recently diagnosed with Ph+ CML: “There’s a great deal of hope, with years and years of research behind this disease. Just make sure to follow your treatment plan to a tee. Every. Single. Day!”


MITCH’S INSIGHTS

This 15‐year veteran of Ph+ CML also offered seven specific strategies on how he successfully incorporated his treatment into his life:

       JUGGLING ON AND OFF DAYS: “You will learn how to predict good days and bad days and operate accordingly. When I became tired, I’d have to be mindful that it wasn’t safe to climb ladders in my job or walk as far and as long as I once did. I knew my clients wanted to see me being engaged and energetic, so I’d reserve those activities for the good days.”

       USING KNOWLEDGE AS POWER: “I made sure to completely understand early on what I needed to do, when I needed to do it, and what was supposed to be happening with my body. Be mindful of side effects. I was probably a little more ignorant than I should have been.”

       SHOWING UP: “Monitoring your blood count is a key part of the process, so when the doctor told me to show up for blood work or other testing, I knew I had to show up.”

      ➠ MINDING THE MEDS: “You might feel so good, you decide to stop taking the meds. But you shouldn’t change your routine without discussing it with your doctor.”

      ➠ LOOKING AT THE BIG PICTURE: “You have to play an active part in your treatment. I’m not engaged in the minutiae, in all the numbers and information the doctors must review, but I always discuss my test results with the doctor or a nurse. I want to know whether everything looks good or whether I had a blip that month. I’m more thumbs up or thumbs down. How am I doing this week and this month? Other patients want to know every number and what it means, but that’s not me.”

      ➠ SETTING THE TIMES FOR TASIGNA: “It might take a while to establish a comfortable routine for taking the medication, since you need it two hours before a meal, and you can’t eat for an hour after the dose. Mornings are super easy for me, since I usually wake up at 6 am and I don’t typically eat breakfast until 8 am. I put the pill on the table next to the bed, pop it in at 6 am and go back to sleep. The timing is more difficult for me in the evening if I’m having dinner with a client or a friend than when I’m home with my wife. It’s not mind‐bending advice, but you have to figure it out on your own.”

      ➠ TRUSTING YOUR DOCS: “It’s more important that I trust the competence and the capability of my doctors and key members of their staff. If that breaks down, I’d look for someone else I can trust. It’s great if you like them, too, but not essential.”

Mitch says his disease is under control, but he’ll likely be on Tasigna for the rest of his life. His blood is tested every six months, and he doesn’t need bone marrow checks at this point, unless something unusual were to show up in his blood. Does he worry? “Heck yeah, every six months it’s like the biggest job interview of my life or waiting to get the biggest contract. I know that Ph+ CML will forever be part of my life, but it doesn’t have to sit at the head of the table. It can sit off to the side just as long as I recognize that it’s there,” he said.

Know your blood count, what the numbers mean, and get a treatment that can help.

To learn more about Tasigna and Mitch’s story, please visit bit.ly/39MghBg.

APPROVED USES

TASIGNA® (nilotinib) capsules is a prescription medicine used to treat:
• Adults with newly diagnosed Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia (CML) in chronic phase

• Adults with Ph+ CML in chronic phase and accelerated phase who no longer benefit from, or did not tolerate, other treatment, including GLEEVEC® (imatinib)

IMPORTANT SAFETY INFORMATION ABOUT TASIGNA® (nilotinib) Capsules

QTc Prolongation and Sudden Death: TASIGNA can cause QTc prolongation, a possibly life‐ threatening heart problem. QTc prolongation causes an irregular heartbeat, which may lead to sudden death. Call your doctor right away if you feel lightheaded, faint, or have an irregular heartbeat while taking TASIGNA. These can be symptoms of QTc prolongation.

• Your doctor should check your heart with a test called an electrocardiogram (ECG)

• Do not take TASIGNA if you have long QTc syndrome or low levels of potassium or magnesium in your blood

• TASIGNA can interact with many medicines and supplements. This may increase your chances for serious and life‐threatening side effects. Do not take any other medicine while taking TASIGNA unless your doctor tells you it is okay to do so

• Food and grapefruit products increase the amount of TASIGNA in your body. This may increase your chances for serious and life‐threatening side effects. Take TASIGNA on an empty stomach

     ° Avoid eating food for at least 2 hours before the dose is taken, and avoid eating food for at least 1 hour after the dose is taken

     ° Avoid grapefruit, grapefruit juice, and any supplement containing grapefruit extract while taking TASIGNA

TASIGNA can cause serious side effects that can even lead to death. During treatment with TASIGNA your doctor will do tests to check for side effects. These tests will check your heart, blood cells (white blood cells, red blood cells, and platelets), electrolytes (potassium, magnesium), cholesterol, blood sugar, and pancreas and liver function. Your doctor may have you stop TASIGNA for some time or lower your dose if you have side effects. You should follow your doctor’s instructions. Serious side effects include:

• Low Blood Counts: Low blood counts are common with TASIGNA but can also be severe. Your doctor will check your blood counts regularly during treatment with TASIGNA. Call your doctor right away if you have symptoms of low blood counts including:

     ° Fever, chills, or other signs of infection

     ° Unexplained bleeding or bruising

     ° Shortness of breath

     ° Unexplained weakness

• Decreased Blood Flow to the Legs, Heart, or Brain: People who have recently been diagnosed with Ph+ CML and take TASIGNA may develop decreased blood flow to the legs, heart, or brain. Get medical help right away if you suddenly develop any of the following symptoms:

     ° Chest pain or discomfort

     ° Numbness or weakness

     ° Problems walking or speaking

     ° Leg pain or your leg feels cold

     ° Change in the skin color of your leg

• Pancreas Inflammation (Pancreatitis): Call your doctor if you have symptoms including sudden stomach area pain with nausea and vomiting

• Liver Problems: TASIGNA can increase your risk of liver problems. People who have had liver problems in the past may be at risk for getting liver problems with TASIGNA. Call your doctor, or get medical help right away if you develop any symptoms of liver problems including stomach area (abdominal) pain, yellow skin/eyes, and dark‐colored urine

• Tumor Lysis Syndrome (TLS): TLS is caused by a fast breakdown of cancer cells. Your doctor may do blood tests to check you for TLS. TLS can cause you to have kidney failure (with the need for dialysis treatment) and/or an abnormal heartbeat

• Bleeding Problems: Serious bleeding problems and death have happened during treatment with TASIGNA. Call your doctor right away if you develop signs and symptoms of bleeding such as uncontrolled bleeding, changes in eyesight, unconsciousness, sudden headache, or sudden confusion about your surroundings

• Total Gastrectomy: Tell your doctor if you have had a surgical procedure involving the removal of the entire stomach (total gastrectomy). Your doctor may need to change your dose

• Lactose: Tell your doctor if you have a severe problem with lactose (milk sugar) or other sugars. TASIGNA capsules contain lactose. Most people who have mild or moderate lactose intolerance can take TASIGNA

• Fluid Retention: Your body may hold too much fluid (fluid retention). Symptoms of fluid retention include shortness of breath, rapid weight gain, and swelling

• Abnormal Growth or Development in Children: Effects on growth and development have happened in children with chronic phase Ph+ CML during treatment with TASIGNA. Some children and adolescents who take TASIGNA may have slower than normal growth

• Pregnancy and Breastfeeding: TASIGNA should not be used during pregnancy since it may harm an unborn baby. If you become pregnant, think you may be pregnant, or are planning to become pregnant, tell your doctor right away. If you are able to become pregnant, your doctor should perform a pregnancy test before you start TASIGNA. Effective birth control should be used during treatment and for at least 14 days after your last TASIGNA dose. Do not breastfeed during treatment with TASIGNA and for at least 14 days after the final dose

• Treatment‐Free Remission in Adults: Your doctor will monitor your CML during treatment with TASIGNA to see if you are in remission. After at least 3 years of treatment with TASIGNA, your doctor may do certain tests to determine if you continue to be in remission. Based on your test results, your doctor will decide if you are eligible to try stopping treatment with TASIGNA. This is called treatment‐free remission (TFR)

     ° Your doctor will carefully monitor your CML during and after you stop taking TASIGNA. If your test results show your CML is no longer in remission, your doctor will restart TASIGNA treatment

     ° It is important that your doctor does frequent monitoring to find out if you need to restart your TASIGNA treatment. Follow your doctor’s instructions about restarting TASIGNA if you are no longer in TFR

• Drug Interactions: TASIGNA can interact with many medicines and supplements. This may increase your chances for serious and life‐threatening side effects. Tell your doctor about all the medicines you take including prescription and over‐the‐counter medicines, vitamins, and herbal supplements

If you need to take antacids (medicines to treat heartburn) do not take them at the same time that you take TASIGNA. If you take:

     ° A medicine to block the amount of acid produced in the stomach (H2 blocker): Take these medicines about 10 hours before you take TASIGNA or about 2 hours after you take TASIGNA

     ° An antacid that contains aluminum hydroxide, magnesium hydroxide,and simethicone to reduce the amount of acid in the stomach: Take these medicines about 2 hours before or about 2 hours after you take TASIGNA

• Common Side Effects in Adults and Children Include:

    • Nausea          • Diarrhea            • Rash             • Cough

    • Headache      • Constipation      • Tiredness      • Muscle and joint pain

    • Itching            • Vomiting            • Fever             • Night sweats

    • Runny or stuffy nose, sneezing, sore throat

• Side Effects in Adults Attempting TFR: If you and your doctor decide that you can stop taking TASIGNA and try TFR, you may have more muscle and bone (musculoskeletal) symptoms than before you stopped treatment. Symptoms may include muscle pain, bone pain, arm and leg pain, spinal pain, and joint pain

Tell your doctor if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of TASIGNA. For more information, ask your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1‐800‐FDA‐1088.

Please see the full Prescribing Information, including the Boxed WARNING, and the TASIGNA Medication Guide.

References

1. American Cancer Society. Chronic Myeloid Leukemia (CML), About Chronic Myeloid Leukemia. 22 February 2016. Available at: https://www.cancer.org/content/dam/CRC/PDF/Public/8684.00.pdf. Accessed November 2019

2. Tasigna [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2019

Faithfully Observing Her Treatment Experience After a Leukemia Diagnosis

This post was developed in collaboration with Novartis

Staying positive and determined: Actual patient Virginia embraces compliance with her CML treatment

Virginia was in her late 40s when she began getting upset stomachs on and off throughout the week. Active and health conscious–her nieces and nephews call her “nuts and berries”–Virginia thought she might be perimenopausal. “When I asked my older sister if my stomach problem could be related, she said, ‘Sometimes, but everyone is different,’” Virginia recalled. After a couple of months, it got to the point where she could eat only half her meal because her stomach was burning pretty intensely, and she felt nauseous.

Between jobs, Virginia had insurance but didn’t have a primary care doctor, so she took herself to the ER in a hospital near her home in Southern California. There she learned her white blood cell count, normally around 10K, had shot up to 700K, and her spleen had enlarged to over four times its normal size. With that came the news that Virginia had Philadelphia chromosome–positive chronic myeloid leukemia in chronic phase, or Ph+ CML, which is a cancer of cells in the blood and bone marrow that starts with a gene mutation called the Philadelphia (Ph) chromosome. This triggers the bone marrow to grow abnormal white blood cells uncontrollably. A form of leukemia most often diagnosed in people over 60, it can occur in younger adults, as it did with Virginia.

“My spleen had been taking on all of the cancer, which is very uncommon, and it extended from the top of my rib cage to my groin. It was laying on top of my stomach and my intestines, which was impacting my digestion. I was lucky it didn’t erupt,” Virginia said. It took 10 days of intense chemotherapy to get her white blood cell count to a place where she could be released from the hospital. “I was devastated. I was scared. I had no idea about my future,” Virginia remembered.

“When the ER oncologist walked into the room and told me that CML is slower growing and easier to treat than some other forms of cancer, I felt a little better,” Virginia said. “‘We’re going to figure this out, and you’re going to be okay,’” said the oncologist, who has remained Virginia’s doctor to this day, nine years later. “We have a total partnership,” Virginia said.

MAKING ‘COMPLIANCE’ COMMONPLACE

Released from the hospital with a treatment plan, Virginia was instructed by her oncologist to make sure to take her medicine and have her blood drawn every three months. “At first, I didn’t understand exactly what the treatment was going to do or the side effects I could have. There’s only so much information you can absorb when you’re newly diagnosed,” Virginia said. “My oncologist didn’t want to expose me to information overload, so she said, ‘Let’s get you stabilized with this routine and see how it goes.’”

“I was on the drug for about four months, which got my numbers within the normal range,” Virginia added, “But the side effects were too great, so my doctor switched me to Tasigna® (nilotinib) capsules, which was a relatively new drug at the time.” Some patients were responding well to it, Virginia’s oncologist told her.

“I had a pretty seamless transition with Tasigna.
Though it can cause side effects for some, such as headache, nausea and potentially other serious outcomes, my numbers kept improving.

It was great to start taking Tasigna,” Virginia remembered feeling.

Virginia has been taking two doses of Tasigna, 12 hours apart, every day for about nine years. Each dose must also be taken two hours before a meal, and patients can’t eat for one hour after the dose. “I had never taken medicine on a strict routine. It was a big‐time shift for me, but my doctor and I made an agreement that I’d be compliant and take the medicine, and I have been,” Virginia explained. “Compliance is a strong word, but I like using it. You have to know you’ll be better off in the long run if you follow the treatment plan to a tee, so I do. I’m grateful that this medication actually exists and that helps me to go with it. Fasting is the hardest part,” Virginia continued.

After her “devastating diagnosis,” Virginia was introduced to a support group of CML survivors who “have walked this road many more years than I have,” she said. They gave her a wealth of good information, as well as strong emotional, practical and financial support. A national patient support group also assigned a volunteer first responder with CML to call Virginia soon after she was diagnosed.

VIRGINIA’S INSIGHTS

Virginia hopes her own experience will help others who have been diagnosed with Ph+ CML, which is why she’s excited to be part of an important Tasigna campaign called Your Blood Demands to Be Heard. “When you take the medicine and have your blood tested on schedule, you’re doing the right thing,” she stressed. A nine‐year veteran of Ph+ CML, Virginia also offered four specific strategies on how she successfully incorporated her disease and its treatment into her life:

      ➠ TIME FOR TASIGNA: “The morning dose is very easy for me because you’re supposed to fast two hours before and an hour after. I take it when I wake up and then wait an hour to eat, and then that dosage is done. Then I take it at 9 pm, two hours after dinner. I just have to be more mindful when I go out to dinner and when I travel between the coasts and have to juggle time zones. I used to set reminders on my phone, but I don’t have to do that anymore.”

     ➠ SUPPORT IS SUPREME: “Find a good support group, even if you don’t feel great, and have a friend, a family member or a caretaker help you get to the doctor, get your blood drawn, take your medicine and take care of yourself, especially during those early days.”

“Support helped me to be compliant. It gave me a place from which to operate and feel safe. When I saw other people doing well, I’d think, ‘I can do that!’ We shared our blood numbers in the support group. The group provided encouragement and accountability. I figured out a way to work with my intimate circle and my support group that allowed me to let the medicine do what it’s supposed to do. I figured out what was going to get in the way of my success, and I deflated those fears and thoughts. There’s nothing like attitude, even if I’m bummed out and having a bad day. I had to get back up and show up again. I chose to do it.”

      ➠ WHERE THERE’S A WILL, THERE’S A WAY: “Besides my positive attitude, the secret to my success is my faith and undying spirit. I eat well. I have fun. I have perspective and a tremendous amount of hope. I got a second chance at life, so I try not to stress out too much. I surround myself with people whom I love and who love me.”

   ➠ NEVER DETERRED BY HER DISEASE: “My legs and large muscle groups would feel lethargic at the beginning, but I’ve been able to get back into a healthy workout routine. I don’t push myself as hard as I once did. I didn’t let my disease prevent me from dancing, playing golf and hiking. I also love to do barre exercise classes.”

Virginia has adjusted to her new normal. Her disease has been under control for a number of years, but she’ll likely be on Tasigna for the rest of her life and will have regular blood tests.

By the way, Virginia is the vice‐president of business development and sales at a startup in the cyber security business. That’s a demanding job, but she’s up to it. “I’ve made some adjustments because of my CML, but I love what I do, which is important to me,” she said.

Know your blood count, what the numbers mean, and get a treatment that can help.

To learn more about Tasigna and Virginia’s story, please visit bit.ly/39MghBg.

APPROVED USES

TASIGNA® (nilotinib) capsules is a prescription medicine used to treat:
• Adults with newly diagnosed Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia (CML) in chronic phase

• Adults with Ph+ CML in chronic phase and accelerated phase who no longer benefit from, or did not tolerate, other treatment, including GLEEVEC® (imatinib)

IMPORTANT SAFETY INFORMATION ABOUT TASIGNA® (nilotinib) Capsules

QTc Prolongation and Sudden Death: TASIGNA can cause QTc prolongation, a possibly life‐ threatening heart problem. QTc prolongation causes an irregular heartbeat, which may lead to sudden death. Call your doctor right away if you feel lightheaded, faint, or have an irregular heartbeat while taking TASIGNA. These can be symptoms of QTc prolongation.

• Your doctor should check your heart with a test called an electrocardiogram (ECG)

• Do not take TASIGNA if you have long QTc syndrome or low levels of potassium or magnesium in your blood

• TASIGNA can interact with many medicines and supplements. This may increase your chances for serious and life‐threatening side effects. Do not take any other medicine while taking TASIGNA unless your doctor tells you it is okay to do so

• Food and grapefruit products increase the amount of TASIGNA in your body. This may increase your chances for serious and life‐threatening side effects. Take TASIGNA on an empty stomach

     ° Avoid eating food for at least 2 hours before the dose is taken, and avoid eating food for at least 1 hour after the dose is taken

     ° Avoid grapefruit, grapefruit juice, and any supplement containing grapefruit extract while taking TASIGNA

TASIGNA can cause serious side effects that can even lead to death. During treatment with TASIGNA your doctor will do tests to check for side effects. These tests will check your heart, blood cells (white blood cells, red blood cells, and platelets), electrolytes (potassium, magnesium), cholesterol, blood sugar, and pancreas and liver function. Your doctor may have you stop TASIGNA for some time or lower your dose if you have side effects. You should follow your doctor’s instructions. Serious side effects include:

• Low Blood Counts: Low blood counts are common with TASIGNA but can also be severe. Your doctor will check your blood counts regularly during treatment with TASIGNA. Call your doctor right away if you have symptoms of low blood counts including:

     ° Fever, chills, or other signs of infection

     ° Unexplained bleeding or bruising

     ° Shortness of breath

     ° Unexplained weakness

• Decreased Blood Flow to the Legs, Heart, or Brain: People who have recently been diagnosed with Ph+ CML and take TASIGNA may develop decreased blood flow to the legs, heart, or brain. Get medical help right away if you suddenly develop any of the following symptoms:

     ° Chest pain or discomfort

     ° Numbness or weakness

     ° Problems walking or speaking

     ° Leg pain or your leg feels cold

     ° Change in the skin color of your leg

• Pancreas Inflammation (Pancreatitis): Call your doctor if you have symptoms including sudden stomach area pain with nausea and vomiting

• Liver Problems: TASIGNA can increase your risk of liver problems. People who have had liver problems in the past may be at risk for getting liver problems with TASIGNA. Call your doctor, or get medical help right away if you develop any symptoms of liver problems including stomach area (abdominal) pain, yellow skin/eyes, and dark‐colored urine

• Tumor Lysis Syndrome (TLS): TLS is caused by a fast breakdown of cancer cells. Your doctor may do blood tests to check you for TLS. TLS can cause you to have kidney failure (with the need for dialysis treatment) and/or an abnormal heartbeat

• Bleeding Problems: Serious bleeding problems and death have happened during treatment with TASIGNA. Call your doctor right away if you develop signs and symptoms of bleeding such as uncontrolled bleeding, changes in eyesight, unconsciousness, sudden headache, or sudden confusion about your surroundings

• Total Gastrectomy: Tell your doctor if you have had a surgical procedure involving the removal of the entire stomach (total gastrectomy). Your doctor may need to change your dose

• Lactose: Tell your doctor if you have a severe problem with lactose (milk sugar) or other sugars. TASIGNA capsules contain lactose. Most people who have mild or moderate lactose intolerance can take TASIGNA

• Fluid Retention: Your body may hold too much fluid (fluid retention). Symptoms of fluid retention include shortness of breath, rapid weight gain, and swelling

• Abnormal Growth or Development in Children: Effects on growth and development have happened in children with chronic phase Ph+ CML during treatment with TASIGNA. Some children and adolescents who take TASIGNA may have slower than normal growth

• Pregnancy and Breastfeeding: TASIGNA should not be used during pregnancy since it may harm an unborn baby. If you become pregnant, think you may be pregnant, or are planning to become pregnant, tell your doctor right away. If you are able to become pregnant, your doctor should perform a pregnancy test before you start TASIGNA. Effective birth control should be used during treatment and for at least 14 days after your last TASIGNA dose. Do not breastfeed during treatment with TASIGNA and for at least 14 days after the final dose

• Treatment‐Free Remission in Adults: Your doctor will monitor your CML during treatment with TASIGNA to see if you are in remission. After at least 3 years of treatment with TASIGNA, your doctor may do certain tests to determine if you continue to be in remission. Based on your test results, your doctor will decide if you are eligible to try stopping treatment with TASIGNA. This is called treatment‐free remission (TFR)

     ° Your doctor will carefully monitor your CML during and after you stop taking TASIGNA. If your test results show your CML is no longer in remission, your doctor will restart TASIGNA treatment

     ° It is important that your doctor does frequent monitoring to find out if you need to restart your TASIGNA treatment. Follow your doctor’s instructions about restarting TASIGNA if you are no longer in TFR

• Drug Interactions: TASIGNA can interact with many medicines and supplements. This may increase your chances for serious and life‐threatening side effects. Tell your doctor about all the medicines you take including prescription and over‐the‐counter medicines, vitamins, and herbal supplements

If you need to take antacids (medicines to treat heartburn) do not take them at the same time that you take TASIGNA. If you take:

     ° A medicine to block the amount of acid produced in the stomach (H2 blocker): Take these medicines about 10 hours before you take TASIGNA or about 2 hours after you take TASIGNA

     ° An antacid that contains aluminum hydroxide, magnesium hydroxide,and simethicone to reduce the amount of acid in the stomach: Take these medicines about 2 hours before or about 2 hours after you take TASIGNA

• Common Side Effects in Adults and Children Include:

    • Nausea          • Diarrhea            • Rash             • Cough

    • Headache      • Constipation      • Tiredness      • Muscle and joint pain

    • Itching            • Vomiting            • Fever             • Night sweats

    • Runny or stuffy nose, sneezing, sore throat

• Side Effects in Adults Attempting TFR: If you and your doctor decide that you can stop taking TASIGNA and try TFR, you may have more muscle and bone (musculoskeletal) symptoms than before you stopped treatment. Symptoms may include muscle pain, bone pain, arm and leg pain, spinal pain, and joint pain

Tell your doctor if you have any side effect that bothers you or does not go away. These are not all of the possible side effects of TASIGNA. For more information, ask your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1‐800‐FDA‐1088.

Please see the full Prescribing Information, including the Boxed WARNING, and the TASIGNA Medication Guide.

References

1. American Cancer Society. Chronic Myeloid Leukemia (CML), About Chronic Myeloid Leukemia. 22 February 2016. Available at: https://www.cancer.org/content/dam/CRC/PDF/Public/8684.00.pdf. Accessed November 2019

2. Tasigna [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2019

Get Younger-Looking Eyes, Instantly!

This is a “sponsored post.” Westmore Beauty compensated FabOverFifty with an advertising sponsorship to write it. Regardless, we only recommend products or services that we believe will be helpful for our readers. All insights and expressed opinions are our own.

Many fab women I know over 50 are exasperated by bags and puffiness under their eyes. Don’t even get them started on those annoying crow’s feet that landed at the outer corners. Regrettably, these unwelcome signs of aging are facts of life, especially after our skin has been exposed to decades of sun. 

I’ve used concealers, serums – even cucumber slices – to reduce the trio of irksome eye problems. Not a single one has lived up to its promises! 

When Westmore Beauty invited me to try its 60-Second Eye Effects Tinted Firming Eye Gel as the editor of a trusted website I thought “sure, what do I have to lose?” I remembered seeing – but not believing – the results when the gel was demonstrated on TV on a 70-year-old woman. “Impossible,” I thought. Now I’d get to see for myself if it really works.

I asked my sister Shelley if she’d apply 60-Second Eye Effects, too, so we could compare the results. Since a photo is worth a thousand words, take a look at how it worked on us!

This stuff is magical! Just like the tube says, it took about 60 seconds to diminish the look of our under-eye discoloration, fine lines and puffiness. Our crow’s feet looked less noticeable too. What’s more, the skin felt and looked firmer and the texture was smoother.  

Actually, it’s Hollywood Magic.

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The Westmore family has been involved in the Hollywood makeup business for over 100 years. They opened the first movie studio hair and makeup department in 1917, glamorized stars including Marilyn Monroe and Shirley McLaine, and did the special effects for movies such as Dr. Jekyll and Mr. Hyde.  

If anyone knows how to create Hollywood makeup magic, it’s the Westmore family. Leveraging decades of artistic genius, technical skill and scientific know-how, the Westmore’s developed the precise formula that makes 60-Second Eye Effects work. 

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The secret is Flex-Tensor Technology, which creates an invisible and flexible film that instantly smooths and tightens under-eye skin, especially the “bags” you want to send packing. Color correctors in the formula help diminish the look of dark circles. Hyaluronic acid provides hydration to help plump the skin. And, special light-reflecting, micro-filler ingredients fill in lines and pores so under-eye skin appears smoother and more radiant. What’s more, the formula includes retinol and vitamin E, two remarkable anti-aging ingredients. 

The results of 60-Second Eye Effects Firming Gel are so unmistakably astonishing that 

all 30 women who participated in a company-sponsored user perception study agreed:

The appearance of crow’s feet and under-eye circles was visibly diminished.

Lines and wrinkles appeared significantly diminished.

Skin felt and appeared firmer.

Skin texture was visibly improved. 

You’ve got to see it for yourself. And, if you’re not as excited as my sister and I, as well as the countless women who’ve written glowing reviews, send back your tube within 60 days for a full refund less S&H! 

There’s more! Your 60-Second Eye Effects Firming Gel comes with two other phenomenal Westmore products for brows and lashes: 

Lash Drama Bold & Beautiful Mascara makes your lashes look dramatically longer and more voluminous by coating it with a revolutionary new texture in an intense black pigment.  

On-The-Go Lasting Effects Brow Gel creates perfectly defined, natural-looking brows with an exclusive blend of specially treated pigments and hair-like fibers. A unique two-sided brow brush helps you shape, soften and smooth the brows. 

They’ll stay full and fab all through the day and night! 

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10 Foolproof Lifestyle Choices to Getting Natural ‘Healthy’ Energy

This is a “sponsored post.” ChromaDex compensated FOF with an advertising sponsorship to write it. Regardless, we only recommend products or services that we believe will be helpful for our readers. All insights and expressed opinions are our own. —Geri Brin

A high powered lawyer at a prestigious firm, my 56-year-old friend Wanda doesn’t feel fully awake until she’s had her first cup of coffee in the morning. She also swears she’d never make it through a long night at the office without guzzling at least one giant mugful.

Coffee might be her quick picker upper, but when Wanda started relying on it throughout the day to give her energy, she realized she wasn’t doing her body any favors. Instead, she felt irritable and anxious, and many nights she couldn’t get to sleep. 

Interestingly, of the 80 percent of adults in the United States who consume caffeine, those between 50-and 64-years old consume the most, according to The Food and Drug Administration. Wanda has plenty of company! 

An overdose of caffeine – think about those sugar-packed drinks in every supermarket across the country –  is no one’s idea of healthy energy. It may get you going in the short term, but have enough of it over the long haul, and it can take its toll on your heartbeat, ability to sleep and nervous system. That’s exactly what Wanda was experiencing. 

Sure, it’s convenient to get a quick shot of energy from a can or a mug when you’re exhausted.  But, it’s far wiser to support your own natural energy levels by incorporating these 10 common sense practices into your daily lifestyle. That way, your body can store energy to call on when you most need it, let’s say during a late night at work or an afternoon at the playground with your toddler grandson.

 


Chronic stress – from a high-pressure job or financial problems, for instance – can cause many types of physical and emotional symptoms, such as tiredness to lack of energy and focus. Determine a way to help reduce your stress, whether it’s seeing a therapist or taking up meditation.

Taking on too much, professionally or personally, can sap your energy. Surely, not every single thing on your “must-do” list has to get done soon, or ever, for that matter. Streamline the list asap! 


Relaxing can provide physical and emotional benefits, such as relieving depression and lowering your heart rate. Laziness is another story. Don’t use energy for days or weeks on end and you’ll actually become more and more fatigued, not to mention raise your health risks. Even if you exercise lightly three days a week for 20 minutes each time, you’ll feel more energized after six weeks, according to a University of Georgia study. Regular exercise delivers oxygen and nutrients to your tissues, boosts strength and endurance, and helps your cardiovascular system to run more efficiently. You’ll probably sleep better, too!  

 

 

We guess you really don’t need another reason to stop smoking, but here it is, anyway: Smoking actually saps your energy by making it harder to sleep. The nicotine in tobacco speeds your heart rate, raises your blood pressure, and stimulates brain-wave activity associated with wakefulness. When you stop smoking, you sleep better and energy returns (provided, of course, you’re not mistreating your body in six other ways). 


While it’s ideal to sleep seven to eight hours a night, sleeping soundly for four hours is far better than tossing and turning for eight. Sleep deprivation has been associated with obesity and related health problems, such as heart disease and diabetes. It can lower your energy level by making you feel fatigued during the day. And, it can impact your immune system, raising your susceptibility to colds and flus and lowering your energy levels for days at a time, according to www.sleepfoundation.org.  

Quality sleep lets your body restore many functions it needs to stay healthy, such as temperature regulation, a strong immune system, steady hormone levels, and good appetite. All of these processes play a role in your energy level. 


Even if your weight is ideal and you exercise regularly, it’s smarter to consume small meals and snacks every few hours than three big meals every day. This gives your brain a steady supply of nutrients and can lower your perception of fatigue, according to Harvard Health Publishing. Foods with a low glycemic index (their sugars are absorbed slowly) may help you avoid the lag in energy that usually occurs after eating quickly absorbed sugars or refined starches. These foods include whole grains, high-fiber vegetables, nuts, and healthy oils such as olive oil. High-carb foods have the highest glycemic indexes. Proteins and fats have glycemic indexes that are almost zero.


 

As we said at the start, caffeine does help increase alertness, but you must drink it judiciously to get its energizing effects. 


 

No denying that a glass of velvety red wine or a super dry vodka martini can make you chill. But avoid drinking at lunch, when the sedative effect is especially strong. And, if you want or need to have energy in the evening, cut out the 5 pm cocktail. Of course, we don’t have to tell you to drink in moderation, do we?

 

Water is the only nutrient that has been shown to enhance performance for all but the most demanding endurance activities. So, unless you’re training for a triathlon, drink it. Not everyone needs eight glasses of water a day, but everyone absolutely needs it for a trillion reasons, including energy. Feeling fatigued is one of the first signs that you’re dehydrated. 



We know, just the thought of sitting in chemistry class again gives you hives. Don’t worry, you don’t have to do that. But please read these few paragraphs about how our bodies make energy, why our energy production naturally ebbs as we age, and a simple thing we can do to help reverse that process.

Dr. Charles Brenner, a Stanford-educated PhD (you’ve got to be impressed with that credential!), has uncovered the pathway between a molecule called nicotinamide riboside (NR), and nicotinamide adenine dinucleotide (NAD), which he argues is the single most important molecule in every single cell of our bodies. 

                 Dr. Charles Brenner

“We all absolutely need NAD,” Dr. Brenner said emphatically. It performs a number of critical functions, such as enabling our cells to convert the fats, proteins and carbohydrates we eat into the energy we need to help us stay in top shape. It also activates sirtuin genes, which regulate cellular aging and the chemical and biological processes that help us maintain healthy and fit lives,  Dr. Brenner reported. 

NR is a form of vitamin B3 that helps our cells to produce NAD. Unfortunately, our levels of NAD substantially decline as our bodies slow down with age. 

Aging is the biggest risk factor for many of the diseases that kill us. Doing cardio and weight-bearing exercises all week, consuming a diet of nutritious whole foods, getting adequate sleep, and staying away from smoking and drinking are all important. “But cells damaged by the inevitable stresses of life, such as aging, look for ways to replenish their NAD, which helps keep them running smoothly,” Dr. Brenner explained.  

An NR supplement actually can reduce the effects of aging on our cells, starting with decreased energy production.

Dr. Brenner is the Chief Scientific Advisor behind TRU NIAGEN®, the only NR supplement directly from ChromaDex, the worldwide patent-holder and innovator behind it. When you take TRU NIAGEN, you’re getting the real benefits of Dr. Brenner’s important discovery, without the side effects of some other supplements.

I’ve been taking TRU NIAGEN® for about three years. I  feel really good, and while I’ve lost some hair as I’ve aged, I  haven’t lost my signature energy. While many claims in the booming nutritional supplement market seem downright absurd, I am living proof that it’s smart to take TRU NIAGEN® since it supports my desire to age the best I can!

 

to age the best you can with Tru Niagen®

Powerful New Supplement Fights The Aging Brain

This is a “sponsored post.” Percepta compensated FOF with an advertising sponsorship to write it. Regardless, we only recommend products or services that we believe will be helpful for our readers. All insights and expressed opinions are our own. —Geri Brin

The place where I learned to think. And the supplement helping to keep my thinking sharp!

I look hipper when my brilliant stylist turns my aging hair from grey to red, and rejuvenated when my dedicated dermatologist treats my aging skin. Now an exciting new supplement is helping me fight my aging brain. After taking two Percepta capsules every morning for one month, I absolutely know my mind is clearer and sharper. I’m back to remembering dates without looking at my calendar, recalling phone numbers without writing them down, and can actually point out each of the 50 states on an outline map. 

I realize that you might disdain my firm decision not to “age gracefully,” at least physically. But, please consider my advice to try Percepta for at least one month if you have even the slightest concern about future memory loss. Because there’s nothing graceful about losing your mind. Although this article may not be the breeziest you’ll read all week, it explains what makes this supplement a game-changer in the study of aging. And why taking it should be a “no brainer.” 

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Simply put, Percepta is a natural plant-based supplement that’s more powerful than any other for targeting out-of-control brain “plaques” and “tangles,” the real reasons we lose memory as we age.  Losing my mind petrifies me!

“We’re all walking around with a bunch of plaques and tangles in our brains, starting in our early to mid-20s,” said Dr. Alan Snow, one of the two neuroscientists behind the new supplement. “We now know they’re there, but no one knows with certainty why they accumulate and cause memory loss in people as they age.”

THE MEMORY LOSS TRILOGY

        Brain tangles of tau protein

Harmful protein fragments that settle between nerve cells in the brain, plaques are destroyed by the immune system in a healthy brain. In some people, however, the immune system actually produces more harmful plaques and neuroinflammation, and kills healthy brain cells. This prevents our nerve cells from talking to each other and prevents us from forming coherent thoughts or sharp memories.  Twisted fibers that live inside the cells, tangles normally support essential structures that carry nutrients and other important substances from one part of the nerve cell to another. In brain aging, this  protein may be abnormal, the structures collapse and the cells die.

Newer research has also uncovered the link between neuroinflammation and memory loss, “although we don’t know the cause of the inflammation,” Dr. Snow added. “We think some people might have problems with brain inflammation later in life. Others can live to be 100 years old and have brains filled with plaques and tangles, but their memories stay basically intact.  They don’t have inflammation in the brain.” Dr Snow calls the combination of plaques, tangles and inflammation “the memory loss trilogy.”

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       Cat’s Claw

THE POWER OF CAT’S CLAW ON THE AGING BRAIN 

Percepta is made with PTI-00703® cat’s claw, a natural plant extract from a wild, woody vine located at a high elevation in the Amazon rainforest. “I’ve been working in the drug development field for brain aging for over 30 years and have never seen a more potent inhibitor of plaques, tangles and inflammation than the cat’s claw that we discovered,” Dr. Snow said confidently. 

Dr. Snow tested this exceptional cat’s claw on mice that had been genetically engineered to grow plaques in their brains as they aged. A major ingredient, newly discovered by the Snow research team, decreased plaques in older mice by 52 to 58% and in younger mice by 74 to 83% over a three-month period. The reduction of brain plaques also led to a 58% improvement in short-term memory, almost back to normal.

THE PERCEPTA DISTINCTION 

Oolong tea acts potently on brain plaques

The Inca civilization actually used cat’s claw for medicinal purposes. Today, dozens of brands market cat’s claw capsules, liquids and powders for everything from fighting viral infections to stimulating the immune system. But the Percepta® cat’s claw, and the exclusive process to extract and concentrate it into a powder, are superior to any other, asserted Dr. Snow, who tested brands from 18 different companies worldwide. A second ingredient in Percepta is MemorTeaTM, a specific oolong tea extract from the mountains of China that acts more potently on plaques than black and green tea. 

Percepta holds 50 global patents that cover cat’s claw for brain health, including cognition, short term memory, focus, concentration and executive function. 

“Exercising, sleeping well, and reducing stress have everything to do with helping to clear out the plaque load that accumulates in your brain so it will function better. One-third of memory loss cases can be prevented by lifestyle changes,” Dr. Snow stressed.  And make sure to add Percepta to your smart schedule. Each two-capsule dose works for about 24 hours, which is how long it takes for plaques to turn over in our brain. “Most people see an increase in memory, focus and/or concentration within a few weeks,” Dr. Snow said.  “One woman with brain tangles from multiple concussions had memories she hasn’t had in 13 years after she started taking Percepta.”

and use code FOF10 (all caps) for 10% off one pack of Percepta for your optimal brain health!

The #1 Selling Anti-Aging Body Treatment For Dry, Crepey Skin Just Got Even Better*

Crepe Erase® compensated FabOverFifty with an advertising sponsorship to write this post. Regardless, we only recommend products or services that we believe will help you. All insights and opinions are our own. —Geri Brin

I try to keep a reserve of the beauty products I love so I’m never caught empty handed. When I was about to reorder one of my favorite products, which makes the skin on my body the smoothest and most hydrated it’s felt in years, I noticed they’ve come out with an improved version. I love when a good thing gets even better, so I ordered right away.

Now, after using new Crepe Erase® Advanced for about six months, I’m more in love than ever!

Dry, delicate skin is common later in life, since our glands naturally produce less oil. And dry skin can crack, especially on our elbows and feet. What’s more, our skin loses its wonderful foundation of collagen and elastin as we age, making it loose and saggy on areas like our neck and chest, inner arms, even on our knees and hands. Looking almost like crepe paper, it’s called “crepey skin.” 

I first discovered Crepe Erase when I was invited to try it as the editor of a popular website. It jumped out at me because I remembered seeing the actress, Jane Seymour, talk about it on TV. She looks sensational, at 68, and has been using Crepe Erase for years, a fine endorsement right there! It’s also a big big seller on QVC, where they call it “anti-aging for your body.”  That definitely got my attention.

Crepe Erase™ isn’t a glorified body lotion. Trust me, it feels like I’ve tried them ALL. The secret ingredient that powers Crepe Erase Advanced is TruFirm Complex, a powerful botanical blend specially formulated for dry, crepey, aging skin. Its three naturally derived extracts–apple, dill and sage–help reinforce our skin’s netting, so the skin can appear tighter and firmer.  Crepe Erase Advanced also contains nine Super Hydrators, including coconut oil, shea butter, cocoa butter, olive oil, beeswax, cassava and Vitamin E to deliver 48 hours of intense hydration. And, they absorb even faster and more effectively than the original formula to visibly smooth, firm and renew the skin.

A breakthrough in skin care science, TruFirm Complex is available exclusively in Crepe Erase! 

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Crepe Erase® is the #1 Selling Anti-Aging Body Treatment System for Dry, Crepey Skin*

(*Based on Crepe Erase® sales data & IRI & NPD sales data for 2017.)

The Essentials Kit includes only two simple steps:

When I shower, I grab my bottle of silky Body Smoothing Pre-Treatment with TruFirm and gentle exfoliators to lift away dead, rough surface cells and make my skin look smoother and more radiant. (By the way, don’t take long, hot showers because they’ll dry your skin even more!) After the shower, I massage the Advanced Body Repair Treatment with TruFirm into the crepey skin around my neck, chest, arms and legs. The Body Smoothing Pre-Treatment has a beautiful, fresh scent and the rich Body Repair Treatment absorbs quickly and isn’t one bit greasy.

As I mentioned earlier, the skin on my body hasn’t felt this smooth and hydrated in many years. I’ve learned that the more consistently you use skincare products, the better the results.

Crepe Erase is so confident that you’ll love its products, it invites you to use them for 60 days, and, if you’re not satisfied, you can return the tubes–EVEN EMPTY–for a full refund, less s&h! This offer even gives me more confidence that these are quality beauty products. Plus, the line is incredibly reasonable in the first place!

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Treat Dry, Crepey Skin All Year

This is a “sponsored post.” Crepe Erase compensated FOF with an advertising sponsorship to write it. Regardless, we only recommend products or services that we believe will be helpful for our readers. All insights and expressed opinions are our own. —Geri Brin

The pipes in one of my bathrooms froze this winter during the incessant frigid temperatures plaguing much of the country. The good news, though, is that my skin continued to feel soft and supple for the first time in years, despite the harsh winter cold. Imagine, 11 degrees outside, and the skin on my body stayed sensationally smooth! My legs, my arms, my hands, my neck– all smooth! I’ll tell you about the thrilling reason why in a moment.

Dry skin is common in later life.

We naturally lose oil glands as we age, and the overheated indoor air we rely on to keep our homes comfortable during the winter makes the problem worse! Think about a favorite pair of leather shoes that’s stretched out and cracked after years of wear.  Like leather, your skin has countless pores that absorb or release moisture. When it releases too much of its moisture, it will dry up. If it dries up too much, cracks may form, especially on your elbows and feet. What’s more, your skin loses its wonderful foundation of collagen and elastin, making it loose and saggy.  

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After 18 Years of Suffering, One Patient Discovers a Treatment That “Finally Worked”

This is a sponsored post. Salix Pharmaceuticals compensated FabOverFifty with an advertising sponsorship to write it. Regardless, we only recommend products or services that we believe will be informative for our readers. —Geri Brin

Her illness first erupted with stomach cramps and pains that would last for weeks at a time. Debilitating, uncontrollable diarrhea followed. Dawn Cobb was 44 and married with three young children. She had always been healthy.

She had colonoscopies, CAT scans, lactose testing, and stool tests, but everything checked out okay. Diets to still the diarrhea didn’t help either. Dawn stopped eating nuts when the doctor thought she might have diverticulosis. She didn’t!  

Dawn’s life was in turmoil. The cramps and pain were bad enough, but never knowing when she’d have a surprise attack of diarrhea, Dawn stopped taking long walks with her friends and other activities that would prevent her from quickly getting to a bathroom. There was no pattern to her symptoms. Periodically, she’d even feel totally fine.

                     Dawn playing tennis

“I owned a retail shop at the time and I literally would bring changes of clothes or have to run home in the middle of the day,” Dawn said. “If I was going out to play tennis, I had to be really careful about what I ate that morning. I could just be sitting at home after having a cup of coffee and ruin my couch cover. I never knew what was going to happen.”

Dawn lived like this for 11 years, trying vainly to find a solution. “You can’t sit back and just accept that this is going to be your way of life. Doctors think you’re stressed, that you want attention, but you can’t let them think that you’re crazy. You have to know this isn’t right. Your body should not be doing this,” Dawn said.

Finally diagnosed with irritable bowel syndrome with diarrhea (IBS-D), Dawn at least knew she wasn’t crazy. But even if she had a name for her disease, there wasn’t a solution that worked for her, so she continued enduring her horrific symptoms for another five years. She also suffered in silence, not telling anyone–including her family–about her illness. I barely shared details about my episodes with my doctor, and she was a woman,” Dawn said.

When symptoms got out of hand about two years ago, and Dawn “just couldn’t take it anymore,” her doctor discussed different treatment options, one of which was surgical intervention. Seeming drastic to her, Dawn went to another gastrointestinal (GI) doctor for a second opinion. That’s when she learned about XIFAXAN® (rifaximin), a two-week treatment that received FDA approval in 2015 specifically to treat IBS-D in adults. Dawn told her long-time doctor about it, who agreed to write a prescription. Patients can be retreated up to two times if symptoms come back.

INDICATION

• XIFAXAN® (rifaximin) 550 mg tablets are indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

IMPORTANT SAFETY INFORMATION
•XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.


(See additional Important Safety Information below and click
 here for full Prescribing Information for XIFAXAN®.)

XIFAXAN ultimately worked for me,” said Dawn, now 62 years old. Dawn responded to her initial course of treatment, but did experience recurring symptoms. She was retreated, and she hasn’t needed to go back to her GI doctor since. “My doctor had mentioned I may have side effects like nausea but I had no nausea at all. I have been able to do things like walk four miles, not petrified that I’ll make it back without an incident. I no longer walk onto a plane afraid of what’s going to happen if the bathroom is occupied,” Dawn explained. “I tell everyone about XIFAXAN. I want other women who suffer with the same symptoms I had, but don’t talk about them, to find out about it. This is my experience with XIFAXAN. If you’re experiencing IBS-D symptoms, talk to your doctor to see if XIFAXAN is right for you.”

To learn more about IBS-D and how XIFAXAN treats it, we spoke to Dr. Caterina Oneto, a gastroenterologist in New York City. 

Dr. Oneto is not giving medical advice. Patients should talk to their healthcare professionals about what is right for them.

FABOVERFIFTY:   WHAT CAUSES IBS-D?

DR. ONETO:  IBS-D is a complex and heterogeneous disease, and we don’t have a complete understanding of its cause or causes. Several factors seem to contribute to it, including an imbalance of the gut microbiota, visceral hypersensitivity (abnormal pain within the inner organs), motility abnormalities (uncommon intestinal contractions), psychosocial stressors  (the mental, emotional, social, and spiritual dimensions of what it means to be healthy), and environmental factors.

WHO IS MOST AFFECTED BY IBS-D?

IBS affects about 10 percent of the population in the United States, and of those patients, about 60 percent have a diarrheal component.

IBS is more common in women; in fact, 60 to 80 percent of participants in most IBS clinical trials are women, generally 25 to 50 years old. But you can get it when you’re older.”

BESIDES THE SYMPTOMS DAWN COBB EXHIBITED (E.G. STOMACH CRAMPS AND PAINS THAT WOULD LAST FOR WEEKS AT A TIME AND DEBILITATING, UNCONTROLLABLE DIARRHEA), ARE THERE OTHER SYMPTOMS ASSOCIATED WITH IBS-D?

IBS-D symptoms can vary widely from one person to the next. However, the two most common are abdominal pain and diarrhea, which is what Dawn experienced. Having frequent and unpredictable diarrhea can be quite disruptive to a person’s personal and professional life and sometimes patients even avoid leaving their homes because they’re afraid to have ‘accidents.'”

WHY DID IT TAKE 18 YEARS FOR DAWN COBB TO GET AN OFFICIAL DIAGNOSIS?

“Sometimes patients don’t seek medical attention for their IBS symptoms. If they’re suffering from diarrhea and abdominal pain they may try to restrict their diet or use over-the-counter drugs. Or, they may accept their symptoms and tell themselves they just have a ‘sensitive stomach’. Patients who seek medical attention for their symptoms may just get antidiarrheals or antispasmodics, but a formal diagnosis will not necessarily be made.”

HOW IS AN IBS-D DIAGNOSIS MADE?

“The diagnosis of IBS-D, in most cases, can be made by taking a good history and performing a physical exam. When evaluating a patient with diarrhea and abdominal pain, it’s important to ask the right questions to determine if other symptoms are present, such as weight loss, rectal bleeding, anemia, and a family history of gastrointestinal cancers, IBD (inflammatory bowel disease) or celiac disease.  These symptoms should make the clinician question the diagnosis of IBS and consider further evaluation that may include lab tests, imaging (like an ultrasound or CT scan) and possibly a colonoscopy and/or endoscopy.”

WHAT IS XIFAXAN AND HOW DOES IT WORK?

“Approved for the treatment of IBS-D in 2015, XIFAXAN is an antibiotic that works on the gut microbiome, a possible factor in IBS-D. Unlike other antibiotics prescribed to combat issues such as sore throats, sinus and urinary infections, XIFAXAN is minimally absorbed into the bloodstream, but stays within the GI tract to inhibit the growth of bacteria. This makes it a well-tolerated medication with a side effect profile similar to placebo. In clinical studies, the most common side effects associated with XIFAXAN for IBS-D were nausea and increase in liver enzymes.”

 XIFAXAN was shown to provide relief from abdominal pain and diarrhea

WHAT IS THE COURSE OF TREATMENT AND SUCCESS RATE?

XIFAXAN is taken by mouth, three times a day, for 14 days. In clinical trials, some patients achieved lasting relief up to six months (relief ranged from 6-24 weeks; average of 10 weeks) after only one course of therapy.

“Those patients whose symptoms return can be retreated up to two additional times. Many patients appreciate XIFAXAN because it lets them control their IBS-D symptoms without taking daily long-term medications.”


INDICATION

XIFAXAN® (rifaximin) 550 mg tablets are indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults.

IMPORTANT SAFETY INFORMATION

      • XIFAXAN is not for everyone. Do not take XIFAXAN if you have a known hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the components in XIFAXAN.

      • If you take antibiotics, like XIFAXAN, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause symptoms ranging in severity from mild diarrhea to life-threatening colitis. Contact your healthcare provider if your diarrhea does not improve or worsens.

      • Talk to your healthcare provider before taking XIFAXAN if you have severe hepatic (liver) impairment, as this may cause increased effects of the medicine.

      • Tell your healthcare provider if you are taking drugs called P-glycoprotein and/or OATPs inhibitors (such as cyclosporine) because using these drugs with XIFAXAN may lead to an increase in the amount of XIFAXAN absorbed by your body.

      • In clinical studies, the most common side effects of XIFAXAN in IBS-D were nausea (feeling sick to your stomach) and an increase in liver enzymes.

      • XIFAXAN may affect warfarin activity when taken together. Tell your healthcare provider if you are taking warfarin because the dose of warfarin may need to be adjusted to maintain proper blood-thinning effect.

      • If you are pregnant, planning to become pregnant, or nursing, talk to your healthcare provider before taking XIFAXAN because XIFAXAN may cause harm to an unborn baby or nursing infant.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183

Email: salixmc@dlss.com

Please click here for full Prescribing Information.

The XIFAXAN product and the XIFAXAN trademark are licensed by Alfasigma S.P.A. to © 2019 Salix Pharmaceuticals or its affiliates.